Inhibitor peptides of transglutaminase 2
Transglutaminase 2 has been shown to be involved in a number of pathological conditions including; coeliac disease, fibrosis, some cancers (breast and pancreas), neurodegenerative diseases (Huntingdon and Alzheimer) and cataract formation. Peptide inhibitors of the transglutaminase family of enzymes have been isolated from soya.
These inhibitors exhibit the greatest potency against transglutaminase 2 with an IC50 value in the nM range. When applied to a human large intestine cell line the inhibitors did not elicit apoptosis but did show intracellular inhibition of transglutaminase 2.This indicates that the soya peptides are cell penetrating inhibitors of transglutaminase 2.
We believe the properties of these peptides could be useful in the alleviation of the symptoms of coeliac disease and fibrosis. They may also be useful as a treatment to prevent the formation of cataracts.
- potent inhibitors of TG2
- cell penetrating properties
- non-toxic to the human cell line tested.
- oral consumption to alleviate the symptoms of coeliac disease
- eye drop application to prevent the formation of cataracts
- potential application in the treatment of fibrosis and certain cancers
- the cell penetrating properties could be used to allow cellular poisons access to the intracellular space.
- to help prevent the regrowth of hair in depilatory creams.
Dr Phillip Bonner
School of Science and Technology
Nottingham Trent University
Nottingham NG11 8NS
Telephone: +44 (0)115 848 8068